Last reviewed: October 2026 · Cleared Peptides research team
Pinealon (Glu-Asp-Arg, EDR) is a short synthetic peptide from the family of peptide bioregulators developed by V. Khavinson and colleagues, each modelled on peptide extracts from a particular tissue — for Pinealon, brain.
Pinealon combines two acidic residues (Glu, Asp) with a C-terminal arginine. It is one of the few bioregulators with an assigned CAS number and is studied in neuronal cell-culture models.
Pinealon Structure and Identifiers
| Name | Pinealon |
|---|---|
| Sequence | Glu-Asp-Arg (EDR) |
| CAS number | 175175-23-2 |
| PubChem CID | 10273502 |
| Molecular formula | C15H26N6O8 |
| Molecular weight | ≈418.4 g/mol |
| Tissue of research origin | Brain |
| Form | Lyophilized powder |
Short Peptide Bioregulators
Khavinson’s group proposed that di-, tri- and tetrapeptides derived from tissue extracts can enter cells and interact with DNA and histone proteins, influencing chromatin structure and tissue-specific gene expression. These peptides are studied mainly in cell-culture and molecular-modelling research. Read the peptide bioregulators overview.
Pinealon and the Glu-Asp (ED) family
Many bioregulators share short sequence cores. Pinealon belongs to the Glu-Asp (ED) family:
| Peptide | Sequence | Tissue of origin |
|---|---|---|
| Pinealon | Glu-Asp-Arg | brain |
| Crystagen | Glu-Asp-Pro | immune tissue |
| Chonluten | Glu-Asp-Gly | bronchial mucosa |
| Ovagen | Glu-Asp-Leu | liver and gastrointestinal tissue |
This summary describes laboratory research only and makes no claim about effects in humans or animals.
Purity Testing and Storage
Every lot of Pinealon supplied by Cleared Peptides is tested by an independent laboratory for identity and purity (or composition, for multi-component preparations), and the lot Certificate of Analysis is published on our COA page. Store lyophilized Pinealon at −20 °C, sealed, dry and protected from light. Allow the vial to reach room temperature before opening. Handle according to your institution’s chemical-hygiene procedures.
Research materials referenced in this guide
Frequently Asked Questions
What is the sequence of Pinealon?
Glu-Asp-Arg (EDR); molecular formula C15H26N6O8, molecular weight ≈418.4 g/mol.
What tissue is Pinealon associated with?
It was modelled on peptide extracts from brain.
Is Pinealon for human use?
No. Cleared Peptides supplies Pinealon for laboratory research use only; it is not for human or veterinary use.
Selected References
Peer-reviewed literature on the compounds discussed in this guide, listed as scientific background for laboratory researchers. Citation does not imply endorsement by the authors or any use other than in-vitro research.
- Khavinson V, et al. Pinealon increases cell viability by suppression of free radical levels and activating proliferative processes. Rejuvenation Res. 2011;14(5):535-41. PubMed 21978084 · DOI
- Fedoreyeva LI, et al. Penetration of short fluorescence-labeled peptides into the nucleus in HeLa cells and in vitro specific interaction of the peptides with deoxyribooligonucleotides and DNA. Biochemistry (Mosc). 2011;76(11):1210-9. PubMed 22117547 · DOI
Laboratory note: solubility depends on salt form and solvent. This guide does not state a single solubility figure. Handling of lyophilized material is described in the peptide storage guide.
Research Use Only Notice
This guide is provided for educational and laboratory reference purposes. It summarizes published, primarily in-vitro and structural research literature and does not describe, recommend or imply any use in humans or animals. Products sold by Cleared Peptides are for laboratory research use only; they are not drugs, foods, cosmetics or dietary supplements, are not FDA-approved, and are not intended to diagnose, treat, cure, mitigate or prevent any disease. No dosing, administration or therapeutic information is provided.
