Last reviewed: October 2026 · Cleared Peptides research team
P-21 (P021) is a small peptidomimetic derived from an active region of ciliary neurotrophic factor (CNTF) and modified with an adamantylated glycine to improve stability. It was developed for laboratory research on neurotrophic signaling.
P-21 Structure and Identifiers
| Name | P-21 |
|---|---|
| Synonyms | P021 |
| Origin | CNTF-derived tetrapeptide with adamantane-modified glycine |
| CAS number | Not available. No public CAS Registry Number was found in the sources reviewed for this guide. |
| Identity | Confirmed per lot COA |
| Form | Powder |
Design
Full-length neurotrophic proteins such as CNTF are large and unstable. P-21 condenses a CNTF-derived epitope into a small, protease-resistant molecule, a common approach in peptidomimetic research.
Published Research Areas
- Neurogenesis and neurotrophic-signaling studies in laboratory models
- Comparison with other neurotrophic tool compounds such as Dihexa and Cerebrolysin
This summary describes laboratory research only and makes no claim about effects in humans or animals.
Purity Testing and Storage
Every lot of P-21 supplied by Cleared Peptides is tested by an independent laboratory for identity and purity (or composition, for multi-component preparations), and the lot Certificate of Analysis is published on our COA page. Store P-21 sealed at −20 °C, dry and protected from light. Handle according to your institution’s chemical-hygiene procedures.
Frequently Asked Questions
What is P-21 derived from?
From an active region of ciliary neurotrophic factor (CNTF).
Is P-21 for human use?
No. Cleared Peptides supplies P-21 for laboratory research use only; it is not for human or veterinary use.
Selected References
A public CAS Registry Number was not found for P-21 (also called P021), a CNTF-derived tetrapeptide described with an adamantane-modified glycine. Identity for each lot is the batch COA. Papers that discuss this peptide in disease models are not summarized here, because this site does not restate treatment or benefit claims.
Laboratory note: solubility depends on salt form and solvent. This guide does not state a single solubility figure. Handling of lyophilized material is described in the peptide storage guide.
Research Use Only Notice
This guide is provided for educational and laboratory reference purposes. It summarizes published, primarily in-vitro and structural research literature and does not describe, recommend or imply any use in humans or animals. Products sold by Cleared Peptides are for laboratory research use only; they are not drugs, foods, cosmetics or dietary supplements, are not FDA-approved, and are not intended to diagnose, treat, cure, mitigate or prevent any disease. No dosing, administration or therapeutic information is provided.
