Last reviewed: October 2026 · Cleared Peptides research team
Dihexa (PNB-0408) is a small, angiotensin IV-derived peptidomimetic developed at Washington State University. In published preclinical literature it is described as a compound reported to bind hepatocyte growth factor (HGF) and modulate HGF/c-Met signaling; some of that literature has since been subject to correction, so researchers should consult current primary sources.
Dihexa Structure and Identifiers
| Name | Dihexa |
|---|---|
| Synonyms | PNB-0408; N-hexanoic-Tyr-Ile-(6)-aminohexanoic amide |
| CAS number | 1401708-83-5 |
| PubChem CID | 129010512 |
| Molecular formula | C27H44N4O5 |
| Molecular weight | ≈504.7 g/mol |
| Type | Modified peptide (angiotensin IV analog) |
| Form | Powder |
Design
Dihexa was derived from angiotensin IV analogs by truncation and N-/C-terminal capping (hexanoic acid and aminohexanoic amide), producing a small, metabolically stable molecule.
Published In-Vitro Research Areas
- HGF dimerization and c-Met activation assays
- Dendritic-spine and synaptogenesis studies in neuronal cultures
This summary describes laboratory research only and makes no claim about effects in humans or animals.
Purity Testing and Storage
Every lot of Dihexa supplied by Cleared Peptides is tested by an independent laboratory for identity and purity (or composition, for multi-component preparations), and the lot Certificate of Analysis is published on our COA page. Store Dihexa sealed at −20 °C, dry and protected from light. Handle according to your institution’s chemical-hygiene procedures.
Frequently Asked Questions
What does Dihexa bind?
It is reported to bind hepatocyte growth factor (HGF) and enhance HGF/c-Met signaling.
Is Dihexa for human use?
No. Cleared Peptides supplies Dihexa for laboratory research use only; it is not for human or veterinary use.
Compound Records
Chemical identifiers for Dihexa are listed in PubChem (CID 129010512).
Selected References
Benoist CC, et al. The procognitive and synaptogenic effects of angiotensin IV-derived peptides are dependent on activation of the hepatocyte growth factor/c-Met system. J Pharmacol Exp Ther. 2014. PubMed 25187433. This paper was retracted in 2025. The proposed HGF/c-Met mechanism is therefore not treated as established on this page. Chemical identifiers already listed above remain the reference data for the compound.
Laboratory note: solubility depends on salt form and solvent. This guide does not state a single solubility figure. Handling of lyophilized material is described in the peptide storage guide.
Research Use Only Notice
This guide is provided for educational and laboratory reference purposes. It summarizes published, primarily in-vitro and structural research literature and does not describe, recommend or imply any use in humans or animals. Products sold by Cleared Peptides are for laboratory research use only; they are not drugs, foods, cosmetics or dietary supplements, are not FDA-approved, and are not intended to diagnose, treat, cure, mitigate or prevent any disease. No dosing, administration or therapeutic information is provided.
