Last reviewed: October 2026 · Cleared Peptides research team
BPC-157 and TB-500 are two of the most frequently researched peptides and are often studied together. They are, however, very different molecules. This page compares them using published structural and in-vitro data.
Side-by-Side Comparison
| BPC-157 | TB-500 (Thymosin Beta-4) | |
|---|---|---|
| CAS | 137525-51-0 | 77591-33-4 |
| Formula | C62H98N16O22 | C212H350N56O78S |
| MW (g/mol) | ≈1419.5 | ≈4963.4 |
| Length | 15 aa | 43 aa (N-acetylated) |
| Origin | Fragment of a gastric-juice protein | Endogenous actin-sequestering peptide |
| Main in-vitro research areas | Cell migration, NO and growth-factor receptor signaling | Actin dynamics, cell migration, angiogenesis signaling |
| Research product | BPC-157 | TB-500 |
Why Researchers Pair Them
Because the two peptides act through unrelated mechanisms — growth-factor/NO signaling for BPC-157 and actin sequestration for Tβ4 — they are commonly examined side by side in cell-migration and cytoskeletal models. For combination studies Cleared Peptides offers a pre-combined BPC-157 + TB-500 blend, plus the GLOW (adds GHK-Cu) and KLOW (adds GHK-Cu and KPV) blends.
Detailed guides: BPC-157 · TB-500.
Research materials referenced in this guide
Frequently Asked Questions
Is BPC-157 the same as TB-500?
No. BPC-157 is a 15-residue gastric-protein fragment; TB-500 is the 43-residue Thymosin Beta-4.
Can I buy BPC-157 and TB-500 together?
Yes, as a pre-combined research blend for laboratory use only.
Selected References
Peer-reviewed literature on the compounds discussed in this guide, listed as scientific background for laboratory researchers. Citation does not imply endorsement by the authors or any use other than in-vitro research.
- Sikiric P, et al. Stable gastric pentadecapeptide BPC 157-NO-system relation. Curr Pharm Des. 2014;20(7):1126-35. PubMed 23755725 · DOI
- Sikiric P, et al. Brain-gut Axis and Pentadecapeptide BPC 157: Theoretical and Practical Implications. Curr Neuropharmacol. 2016;14(8):857-865. PubMed 27138887 · DOI
- Nachmias VT. Small actin-binding proteins: the beta-thymosin family. Curr Opin Cell Biol. 1993;5(1):56-62. PubMed 8448031 · DOI
- Dedova IV, et al. Thymosin beta4 induces a conformational change in actin monomers. Biophys J. 2006;90(3):985-92. PubMed 16272441 · DOI
Laboratory note: solubility depends on salt form and solvent. This guide does not state a single solubility figure. Handling of lyophilized material is described in the peptide storage guide.
Research Use Only Notice
This guide is provided for educational and laboratory reference purposes. It summarizes published, primarily in-vitro and structural research literature and does not describe, recommend or imply any use in humans or animals. Products sold by Cleared Peptides are for laboratory research use only; they are not drugs, foods, cosmetics or dietary supplements, are not FDA-approved, and are not intended to diagnose, treat, cure, mitigate or prevent any disease. No dosing, administration or therapeutic information is provided.
