Last reviewed: October 2026 · Cleared Peptides research team
UBT-251 (UBT251) is an investigational synthetic peptide described as a triple agonist at the GLP-1, GIP and glucagon receptors — the same receptor profile as retatrutide. Public structural detail is limited, so identity is confirmed per lot on the COA.
UBT-251 Structure and Identifiers
| Name | UBT-251 |
|---|---|
| Code | UBT251 |
| Class | Synthetic peptide; GLP-1R/GIPR/GCGR triple agonist (investigational) |
| CAS number | Not available. No public CAS Registry Number was found in the sources reviewed for this guide. |
| Identity | Confirmed per lot COA |
| Form | Lyophilized powder |
Triple Agonists in Research
Unimolecular triple agonists let researchers study combined activation of GLP-1, GIP and glucagon receptors in one ligand. UBT-251 provides a second triple-agonist chemotype for comparison with retatrutide in receptor-selectivity and cAMP assays.
Comparison
| Compound | Receptors (described) | CAS |
|---|---|---|
| Retatrutide | GIPR + GLP-1R + GCGR | 2381089-83-2 |
| UBT-251 | GIPR + GLP-1R + GCGR | Not publicly listed |
| Tirzepatide | GIPR + GLP-1R | 2023788-19-2 |
This summary describes laboratory research only and makes no claim about effects in humans or animals.
Purity Testing and Storage
Every lot of UBT-251 supplied by Cleared Peptides is tested by an independent laboratory for identity and purity (or composition, for multi-component preparations), and the lot Certificate of Analysis is published on our COA page. Store lyophilized UBT-251 at −20 °C, sealed, dry and protected from light. Allow the vial to reach room temperature before opening and minimize freeze–thaw cycles. Handle according to your institution’s chemical-hygiene procedures.
Research materials referenced in this guide
Frequently Asked Questions
How does UBT-251 compare with retatrutide?
Both are described as GLP-1/GIP/glucagon triple agonists; they are distinct molecules useful for side-by-side receptor studies.
Is UBT-251 for human use?
No. Cleared Peptides supplies UBT-251 for laboratory research use only; it is not for human or veterinary use.
Selected References
A public CAS Registry Number and a peer-reviewed PubMed record that defines a formula and sequence for UBT-251 were not identified when this guide was reviewed. Identity for each lot is the batch COA.
Laboratory note: solubility depends on salt form and solvent. This guide does not state a single solubility figure. Handling of lyophilized material is described in the peptide storage guide.
Research Use Only Notice
This guide is provided for educational and laboratory reference purposes. It summarizes published, primarily in-vitro and structural research literature and does not describe, recommend or imply any use in humans or animals. Products sold by Cleared Peptides are for laboratory research use only; they are not drugs, foods, cosmetics or dietary supplements, are not FDA-approved, and are not intended to diagnose, treat, cure, mitigate or prevent any disease. No dosing, administration or therapeutic information is provided.
