Last reviewed: October 2026 · Cleared Peptides research team
SLU-PP-332 is a synthetic small molecule developed at Saint Louis University as an agonist of the estrogen-related receptors ERRα, ERRβ and ERRγ — orphan nuclear receptors that regulate genes involved in mitochondrial biogenesis and oxidative metabolism.
SLU-PP-332 Structure and Identifiers
| Name | SLU-PP-332 |
|---|---|
| CAS number | 303760-60-3 |
| PubChem CID | 5338394 |
| Molecular formula | C18H14N2O2 |
| Molecular weight | ≈290.3 g/mol |
| Type | Small molecule (not a peptide) |
| Form | Powder |
Estrogen-Related Receptors
Despite their name, ERRs do not bind estrogen. They are constitutively active nuclear receptors that partner with the co-activator PGC-1α. Synthetic agonists such as SLU-PP-332 are used to probe ERR-driven transcription in cell models.
Published In-Vitro Research Areas
- ERR reporter and target-gene expression assays
- Mitochondrial-biogenesis studies in muscle-cell cultures
This summary describes laboratory research only and makes no claim about effects in humans or animals.
Purity Testing and Storage
Every lot of SLU-PP-332 supplied by Cleared Peptides is tested by an independent laboratory for identity and purity (or composition, for multi-component preparations), and the lot Certificate of Analysis is published on our COA page. Store SLU-PP-332 sealed at −20 °C, dry and protected from light. Handle according to your institution’s chemical-hygiene procedures.
Research materials referenced in this guide
Frequently Asked Questions
Does SLU-PP-332 bind the estrogen receptor?
No. It targets the estrogen-related receptors (ERRs), which are distinct from estrogen receptors.
Is SLU-PP-332 for human use?
No. Cleared Peptides supplies SLU-PP-332 for laboratory research use only; it is not for human or veterinary use.
Selected References
Billon C, et al. Synthetic ERRα/β/γ agonist induces an ERRα-dependent acute aerobic exercise response and enhances exercise capacity. ACS Chem Biol. 2023;18(4):756-771. Cited as the chemical-biology report that identifies SLU-PP-332 as a synthetic ligand of the estrogen-related receptors in cell assays, with the highest reported potency at ERRα. Outcome wording in the paper title is not repeated as a claim on this site.
Laboratory note: solubility depends on salt form and solvent. This guide does not state a single solubility figure. Handling of lyophilized material is described in the peptide storage guide.
Research Use Only Notice
This guide is provided for educational and laboratory reference purposes. It summarizes published, primarily in-vitro and structural research literature and does not describe, recommend or imply any use in humans or animals. Products sold by Cleared Peptides are for laboratory research use only; they are not drugs, foods, cosmetics or dietary supplements, are not FDA-approved, and are not intended to diagnose, treat, cure, mitigate or prevent any disease. No dosing, administration or therapeutic information is provided.
