Last reviewed: October 2026 · Cleared Peptides research team
Mechano growth factor (MGF) is the name given to an IGF-1 splice variant (IGF-1Ec in humans) whose unique C-terminal E-domain peptide has been studied in muscle-cell research. PEG-MGF is a synthetic version of that E-peptide conjugated to polyethylene glycol.
PEG-MGF Structure and Identifiers
| Name | PEG-MGF |
|---|---|
| Description | PEG-conjugated 24-amino-acid MGF E-peptide |
| CAS number | Not available. A public CAS Registry Number has not been assigned to this sequence in the sources reviewed for this guide. |
| Molecular formula | Pegylated peptide (variable) |
| Form | Lyophilized powder |
Why PEGylate?
Attaching polyethylene glycol increases hydrodynamic size and shields a peptide from proteolysis, extending its stability in biological media. PEG-MGF is used to study how PEGylation changes peptide behavior compared with the free E-peptide.
Published In-Vitro Research Areas
- Myoblast and satellite-cell proliferation assays
- IGF-1 splice-variant biology
- Peptide PEGylation and stability studies
This summary describes laboratory research only and makes no claim about effects in humans or animals.
Purity Testing and Storage
Every lot of PEG-MGF supplied by Cleared Peptides is tested by an independent laboratory for identity and purity (or composition, for multi-component preparations), and the lot Certificate of Analysis is published on our COA page. Store lyophilized PEG-MGF at −20 °C, sealed, dry and protected from light. Allow the vial to reach room temperature before opening and minimize freeze–thaw cycles. Handle according to your institution’s chemical-hygiene procedures.
Research materials referenced in this guide
Frequently Asked Questions
Is MGF the same as IGF-1?
No. MGF refers to an IGF-1 splice variant; the research peptide corresponds to its unique E-domain rather than mature IGF-1.
Is PEG-MGF for human use?
No. Cleared Peptides supplies PEG-MGF for laboratory research use only; it is not for human or veterinary use.
Selected References
Peer-reviewed literature on the compounds discussed in this guide, listed as scientific background for laboratory researchers. Citation does not imply endorsement by the authors or any use other than in-vitro research.
- Dai Z, et al. IGF-IEc expression, regulation and biological function in different tissues. Growth Horm IGF Res. 2010;20(4):275-81. PubMed 20494600 · DOI
Laboratory note: solubility depends on salt form and solvent. This guide does not state a single solubility figure. Handling of lyophilized material is described in the peptide storage guide.
Research Use Only Notice
This guide is provided for educational and laboratory reference purposes. It summarizes published, primarily in-vitro and structural research literature and does not describe, recommend or imply any use in humans or animals. Products sold by Cleared Peptides are for laboratory research use only; they are not drugs, foods, cosmetics or dietary supplements, are not FDA-approved, and are not intended to diagnose, treat, cure, mitigate or prevent any disease. No dosing, administration or therapeutic information is provided.
