Last reviewed: October 2026 · Cleared Peptides research team
Nisotirostide (LY3457263) is a synthetic, lipidated analog of peptide YY (PYY). Native PYY(3–36) is a selective agonist of the neuropeptide Y2 receptor (Y2R), and nisotirostide is used in research on this receptor family alongside incretin-receptor peptides.
Nisotirostide Structure and Identifiers
| Name | Nisotirostide |
|---|---|
| Code | LY3457263 |
| CAS number | 2663844-45-7 |
| PubChem CID | 171921325 |
| Molecular formula | C230H343N59O65 |
| Molecular weight | ≈4974.6 g/mol |
| Class | Lipidated PYY analog peptide |
| Form | Lyophilized powder |
PYY and the Y2 Receptor
PYY is released from intestinal L-cells together with GLP-1. Cleavage of PYY(1–36) by DPP-4 yields PYY(3–36), which shows selectivity for Y2R, a Gi-coupled GPCR. Lipidation is used to extend peptide half-life.
Related Research Compounds
Compare with retatrutide, tirzepatide and semaglutide, which target incretin receptors rather than NPY receptors.
This summary describes laboratory research only and makes no claim about effects in humans or animals.
Purity Testing and Storage
Every lot of Nisotirostide supplied by Cleared Peptides is tested by an independent laboratory for identity and purity (or composition, for multi-component preparations), and the lot Certificate of Analysis is published on our COA page. Store lyophilized Nisotirostide at −20 °C, sealed, dry and protected from light. Allow the vial to reach room temperature before opening and minimize freeze–thaw cycles. Handle according to your institution’s chemical-hygiene procedures.
Research materials referenced in this guide
Frequently Asked Questions
What receptor family does nisotirostide target?
Neuropeptide Y receptors, with PYY analogs typically selective for Y2R.
Is Nisotirostide for human use?
No. Cleared Peptides supplies Nisotirostide for laboratory research use only; it is not for human or veterinary use.
Selected References
Peer-reviewed literature on the compounds discussed in this guide, listed as scientific background for laboratory researchers. Citation does not imply endorsement by the authors or any use other than in-vitro research.
- Ghamari-Langroudi M, et al. PYY3-36 inhibits the action potential firing activity of POMC neurons of arcuate nucleus through postsynaptic Y2 receptors. Cell Metab. 2005;2(3):191-9. PubMed 16154101 · DOI
Laboratory note: solubility depends on salt form and solvent. This guide does not state a single solubility figure. Handling of lyophilized material is described in the peptide storage guide.
Research Use Only Notice
This guide is provided for educational and laboratory reference purposes. It summarizes published, primarily in-vitro and structural research literature and does not describe, recommend or imply any use in humans or animals. Products sold by Cleared Peptides are for laboratory research use only; they are not drugs, foods, cosmetics or dietary supplements, are not FDA-approved, and are not intended to diagnose, treat, cure, mitigate or prevent any disease. No dosing, administration or therapeutic information is provided.
