Last reviewed: October 2026 · Cleared Peptides research team
Kisspeptin-10 (KP-10, metastin 45–54) is the C-terminal decapeptide shared by all kisspeptins encoded by the KISS1 gene. It is the shortest fragment with full agonist activity at the kisspeptin receptor KISS1R (GPR54).
Kisspeptin-10 Structure and Identifiers
| Name | Kisspeptin-10 |
|---|---|
| Synonyms | KP-10; metastin (45–54) |
| CAS number | 374675-21-5 |
| PubChem CID | 25240297 |
| Molecular formula | C63H83N17O14 |
| Molecular weight | ≈1302.4 g/mol |
| Sequence | Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2 |
| Form | Lyophilized powder |
Discovery
KISS1 was first identified as a metastasis-suppressor gene, and its peptide product was named metastin. In 2001 several groups identified the orphan receptor GPR54 as its receptor. The C-terminal RF-amide motif is essential for receptor activation.
Published In-Vitro Research Areas
- KISS1R binding and Gq/calcium-signaling assays
- Neuroendocrine cell models
- Structure–activity studies of RF-amide peptides
This summary describes laboratory research only and makes no claim about effects in humans or animals.
Purity Testing and Storage
Every lot of Kisspeptin-10 supplied by Cleared Peptides is tested by an independent laboratory for identity and purity (or composition, for multi-component preparations), and the lot Certificate of Analysis is published on our COA page. Store lyophilized Kisspeptin-10 at −20 °C, sealed, dry and protected from light. Allow the vial to reach room temperature before opening and minimize freeze–thaw cycles. Handle according to your institution’s chemical-hygiene procedures.
Research materials referenced in this guide
Frequently Asked Questions
What receptor does kisspeptin-10 activate?
KISS1R, also known as GPR54.
Is Kisspeptin-10 for human use?
No. Cleared Peptides supplies Kisspeptin-10 for laboratory research use only; it is not for human or veterinary use.
Selected References
Peer-reviewed literature on the compounds discussed in this guide, listed as scientific background for laboratory researchers. Citation does not imply endorsement by the authors or any use other than in-vitro research.
- Kotani M, et al. The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54. J Biol Chem. 2001;276(37):34631-6. PubMed 11457843 · DOI
- Zhang X, et al. Functional examination of novel kisspeptin phosphinic peptides. PLoS One. 2018;13(4):e0195089. PubMed 29614094 · DOI
- Smith JT, et al. Stimulation of growth hormone by kisspeptin antagonists in ewes. J Endocrinol. 2018;237(2):165-173. PubMed 29549187 · DOI
Laboratory note: solubility depends on salt form and solvent. This guide does not state a single solubility figure. Handling of lyophilized material is described in the peptide storage guide.
Research Use Only Notice
This guide is provided for educational and laboratory reference purposes. It summarizes published, primarily in-vitro and structural research literature and does not describe, recommend or imply any use in humans or animals. Products sold by Cleared Peptides are for laboratory research use only; they are not drugs, foods, cosmetics or dietary supplements, are not FDA-approved, and are not intended to diagnose, treat, cure, mitigate or prevent any disease. No dosing, administration or therapeutic information is provided.
