Last reviewed: October 2026 · Cleared Peptides research team
Epitalon (also spelled epithalon; Ala-Glu-Asp-Gly) is a synthetic tetrapeptide developed by Vladimir Khavinson and colleagues, based on the amino-acid composition of epithalamin, a peptide extract of the pineal gland. It is the best-known member of the short-peptide bioregulator family.
In this guide:
Epitalon Structure and Identifiers
| Name | Epitalon (Epithalon) |
|---|---|
| CAS number | 307297-39-8 |
| PubChem CID | 219042 |
| Molecular formula | C14H22N4O9 |
| Molecular weight | ≈390.3 g/mol |
| Sequence | Ala-Glu-Asp-Gly (AEDG) |
| Form | Lyophilized powder |
Short Peptide Bioregulators
Khavinson’s group proposed that very short peptides (2–4 residues) derived from tissue extracts can interact with DNA and chromatin to influence gene expression. Epitalon is one of a series of such peptides; related compounds include Pinealon, Vilon, Cortagen and Livagen.
Published In-Vitro Research Areas
- Telomerase activity and telomere-length studies in cultured somatic cells
- Chromatin condensation and gene-expression studies
- Peptide–DNA interaction modelling
This summary describes laboratory research only and makes no claim about effects in humans or animals.
Cleared Peptides supplies Epitalon and a range of bioregulator peptides, each with a lot COA on our COA page.
Research materials referenced in this guide
Frequently Asked Questions
Is Epitalon the same as Epithalon?
Yes. Both spellings refer to the tetrapeptide Ala-Glu-Asp-Gly (CAS 307297-39-8).
Where does Epitalon come from?
It is a synthetic peptide designed from the composition of epithalamin, a pineal-gland extract.
Is Epitalon for human use?
No. It is supplied for laboratory research use only.
Selected References
Peer-reviewed literature on the compounds discussed in this guide, listed as scientific background for laboratory researchers. Citation does not imply endorsement by the authors or any use other than in-vitro research.
- Araj SK, et al. Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties. Int J Mol Sci. 2025;26(6). PubMed 40141333 · DOI
- Khavinson VK. Tissue-specific effects of peptides. Bull Exp Biol Med. 2001;132(2):807-8. PubMed 11713572 · DOI
Laboratory note: solubility depends on salt form and solvent. This guide does not state a single solubility figure. Handling of lyophilized material is described in the peptide storage guide.
Research Use Only Notice
This guide is provided for educational and laboratory reference purposes. It summarizes published, primarily in-vitro and structural research literature and does not describe, recommend or imply any use in humans or animals. Products sold by Cleared Peptides are for laboratory research use only; they are not drugs, foods, cosmetics or dietary supplements, are not FDA-approved, and are not intended to diagnose, treat, cure, mitigate or prevent any disease. No dosing, administration or therapeutic information is provided.
