Last reviewed: October 2026 · Cleared Peptides research team
DSIP (delta sleep-inducing peptide) is a nonapeptide isolated in 1977 by Schoenenberger and Monnier from the cerebral venous blood of rabbits. Despite decades of study, its endogenous gene and receptor remain unidentified, which keeps it an intriguing subject of neuropeptide research.
DSIP Structure and Identifiers
| Name | DSIP |
|---|---|
| Synonyms | Delta sleep-inducing peptide |
| CAS number | 62568-57-4 |
| PubChem CID | 68816 |
| Molecular formula | C35H48N10O15 |
| Molecular weight | ≈848.8 g/mol |
| Sequence | Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu |
| Form | Lyophilized powder |
Published Research Areas
- Peptide stability and transport studies
- Interaction with neurotransmitter systems in laboratory models
- Search for endogenous DSIP-like immunoreactivity
This summary describes laboratory research only and makes no claim about effects in humans or animals.
Purity Testing and Storage
Every lot of DSIP supplied by Cleared Peptides is tested by an independent laboratory for identity and purity (or composition, for multi-component preparations), and the lot Certificate of Analysis is published on our COA page. Store lyophilized DSIP at −20 °C, sealed, dry and protected from light. Allow the vial to reach room temperature before opening and minimize freeze–thaw cycles. Handle according to your institution’s chemical-hygiene procedures.
Frequently Asked Questions
When was DSIP discovered?
It was first isolated and sequenced in 1977.
Is DSIP for human use?
No. Cleared Peptides supplies DSIP for laboratory research use only; it is not for human or veterinary use.
Selected References
Peer-reviewed literature on the compounds discussed in this guide, listed as scientific background for laboratory researchers. Citation does not imply endorsement by the authors or any use other than in-vitro research.
- Monnier M, et al. The delta sleep inducing peptide (DSIP). Comparative properties of the original and synthetic nonapeptide. Experientia. 1977;33(4):548-52. PubMed 862769 · DOI
- Marks N, et al. Degradation of delta sleep inducing peptide (DSIP) and its analogs by brain extracts. Brain Res Bull. 1977;2(6):491-3. PubMed 606344 · DOI
Laboratory note: solubility depends on salt form and solvent. This guide does not state a single solubility figure. Handling of lyophilized material is described in the peptide storage guide.
Research Use Only Notice
This guide is provided for educational and laboratory reference purposes. It summarizes published, primarily in-vitro and structural research literature and does not describe, recommend or imply any use in humans or animals. Products sold by Cleared Peptides are for laboratory research use only; they are not drugs, foods, cosmetics or dietary supplements, are not FDA-approved, and are not intended to diagnose, treat, cure, mitigate or prevent any disease. No dosing, administration or therapeutic information is provided.
