Last reviewed: October 2026 · Cleared Peptides research team
Cagrilintide (AM833) is a long-acting, acylated analog of amylin — a 37-residue peptide hormone co-secreted with insulin. It was described by Kruse and colleagues in 2021 as a non-selective agonist at amylin and calcitonin receptors.
Cagrilintide Structure and Identifiers
| Name | Cagrilintide |
|---|---|
| Codes | AM833; NN0174-0833 |
| CAS number | 1415456-99-3 |
| PubChem CID | 171397054 |
| Molecular formula | C194H312N54O59S2 |
| Molecular weight | ≈4409.0 g/mol |
| Structure | 37-residue acylated amylin analog (Cys2–Cys7 disulfide) |
| Form | Lyophilized powder |
Design
Native human amylin aggregates into amyloid fibrils. Cagrilintide’s sequence substitutions reduce fibrillation, and a C20 fatty diacid side chain provides albumin binding for an extended half-life — a design shared with incretin analogs such as semaglutide.
Receptor Pharmacology
Amylin receptors (AMY1–3) are formed when the calcitonin receptor (CTR) associates with receptor activity-modifying proteins (RAMP1–3). Cagrilintide activates AMY receptors and CTR in cell-based cAMP assays.
See also: cagrilintide + semaglutide (CagriSema).
This summary describes laboratory research only and makes no claim about effects in humans or animals.
Purity Testing and Storage
Every lot of Cagrilintide supplied by Cleared Peptides is tested by an independent laboratory for identity and purity (or composition, for multi-component preparations), and the lot Certificate of Analysis is published on our COA page. Store lyophilized Cagrilintide at −20 °C, sealed, dry and protected from light. Allow the vial to reach room temperature before opening and minimize freeze–thaw cycles. Handle according to your institution’s chemical-hygiene procedures.
Frequently Asked Questions
What is the CAS number of cagrilintide?
1415456-99-3; molecular formula C194H312N54O59S2.
Is Cagrilintide for human use?
No. Cleared Peptides supplies Cagrilintide for laboratory research use only; it is not for human or veterinary use.
Selected References
Peer-reviewed literature on the compounds discussed in this guide, listed as scientific background for laboratory researchers. Citation does not imply endorsement by the authors or any use other than in-vitro research.
- Kruse T, et al. Development of Cagrilintide, a Long-Acting Amylin Analogue. J Med Chem. 2021;64(15):11183-11194. PubMed 34288673 · DOI
- Cao J, et al. Structural and dynamic features of cagrilintide binding to calcitonin and amylin receptors. Nat Commun. 2025;16(1):3389. PubMed 40204768 · DOI
- Gu YM, et al. Structural and mechanistic insights into dual activation of cagrilintide in amylin and calcitonin receptors. Acta Pharmacol Sin. 2026;47(1):162-172. PubMed 40847076 · DOI
Laboratory note: solubility depends on salt form and solvent. This guide does not state a single solubility figure. Handling of lyophilized material is described in the peptide storage guide.
Research Use Only Notice
This guide is provided for educational and laboratory reference purposes. It summarizes published, primarily in-vitro and structural research literature and does not describe, recommend or imply any use in humans or animals. Products sold by Cleared Peptides are for laboratory research use only; they are not drugs, foods, cosmetics or dietary supplements, are not FDA-approved, and are not intended to diagnose, treat, cure, mitigate or prevent any disease. No dosing, administration or therapeutic information is provided.
