Last reviewed: October 2026 · Cleared Peptides research team
ARA-290 (cibinetide, pHBSP) is an 11-amino-acid peptide designed from the helix-B surface of erythropoietin (EPO). It was developed to engage the so-called innate repair receptor — a heteromer of the EPO receptor and the β-common receptor (CD131) — without activating the classical EPO receptor homodimer.
ARA-290 Structure and Identifiers
| Name | ARA-290 (cibinetide) |
|---|---|
| Synonyms | pHBSP (pyroglutamate helix B surface peptide) |
| CAS number | 1208243-50-8 |
| PubChem CID | 91810664 |
| Molecular formula | C51H84N16O21 |
| Molecular weight | ≈1257.3 g/mol |
| Sequence | pGlu-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser |
| Form | Lyophilized powder |
Receptor Selectivity
Because ARA-290 lacks the EPO domains needed for homodimer activation, it is used in receptor-selectivity studies that separate EPOR/CD131 signaling from classical erythropoietic signaling.
Published In-Vitro Research Areas
- EPOR/CD131 receptor pharmacology
- Inflammatory-signaling cell models
- Structure–activity studies of EPO-derived peptides
This summary describes laboratory research only and makes no claim about effects in humans or animals.
Purity Testing and Storage
Every lot of ARA-290 supplied by Cleared Peptides is tested by an independent laboratory for identity and purity (or composition, for multi-component preparations), and the lot Certificate of Analysis is published on our COA page. Store lyophilized ARA-290 at −20 °C, sealed, dry and protected from light. Allow the vial to reach room temperature before opening and minimize freeze–thaw cycles. Handle according to your institution’s chemical-hygiene procedures.
Research materials referenced in this guide
Frequently Asked Questions
Is ARA-290 the same as cibinetide?
Yes. Cibinetide is the nonproprietary name for ARA-290.
Is ARA-290 for human use?
No. Cleared Peptides supplies ARA-290 for laboratory research use only; it is not for human or veterinary use.
Selected References
Peer-reviewed literature on the compounds discussed in this guide, listed as scientific background for laboratory researchers. Citation does not imply endorsement by the authors or any use other than in-vitro research.
- Bohr S, et al. Modulation of cellular stress response via the erythropoietin/CD131 heteroreceptor complex in mouse mesenchymal-derived cells. J Mol Med (Berl). 2015;93(2):199-210. PubMed 25373867 · DOI
- Polgárová K, et al. The erythropoietin analogue ARA290 modulates the innate immune response and reduces Escherichia coli invasion into urothelial cells. FEMS Immunol Med Microbiol. 2011;62(2):190-6. PubMed 21410562 · DOI
Laboratory note: solubility depends on salt form and solvent. This guide does not state a single solubility figure. Handling of lyophilized material is described in the peptide storage guide.
Research Use Only Notice
This guide is provided for educational and laboratory reference purposes. It summarizes published, primarily in-vitro and structural research literature and does not describe, recommend or imply any use in humans or animals. Products sold by Cleared Peptides are for laboratory research use only; they are not drugs, foods, cosmetics or dietary supplements, are not FDA-approved, and are not intended to diagnose, treat, cure, mitigate or prevent any disease. No dosing, administration or therapeutic information is provided.
