Last reviewed: October 2026 · Cleared Peptides research team
AOD-9604 is a synthetic 16-residue peptide corresponding to the C-terminal region (residues 177–191) of human growth hormone with an additional N-terminal tyrosine. It was designed to study the activity of this hGH region independently of the full hormone.
AOD-9604 Structure and Identifiers
| Name | AOD-9604 |
|---|---|
| Synonyms | hGH fragment 177–191 (Tyr-modified) |
| CAS number | 221231-10-3 |
| PubChem CID | 71300630 |
| Molecular formula | C78H123N23O23S2 |
| Molecular weight | ≈1815.1 g/mol |
| Sequence | Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe |
| Form | Lyophilized powder |
Structure
The two cysteines (Cys182 and Cys189 in hGH numbering) can form an intramolecular disulfide, reproducing a loop present in the native hormone. The fragment does not contain the hGH receptor-binding sites, which is why it is used in fragment-based structure–function studies.
Published In-Vitro Research Areas
- Lipolysis-signaling assays in adipocyte models
- Growth-hormone structure–function comparisons
This summary describes laboratory research only and makes no claim about effects in humans or animals.
Purity Testing and Storage
Every lot of AOD-9604 supplied by Cleared Peptides is tested by an independent laboratory for identity and purity (or composition, for multi-component preparations), and the lot Certificate of Analysis is published on our COA page. Store lyophilized AOD-9604 at −20 °C, sealed, dry and protected from light. Allow the vial to reach room temperature before opening and minimize freeze–thaw cycles. Handle according to your institution’s chemical-hygiene procedures.
Research materials referenced in this guide
Frequently Asked Questions
Is AOD-9604 the same as growth hormone?
No. It is a 16-residue fragment of the 191-residue hormone and lacks its receptor-binding domains.
Is AOD-9604 for human use?
No. Cleared Peptides supplies AOD-9604 for laboratory research use only; it is not for human or veterinary use.
Selected References
Peer-reviewed literature on the compounds discussed in this guide, listed as scientific background for laboratory researchers. Citation does not imply endorsement by the authors or any use other than in-vitro research.
- Cox HD, et al. Detection and in vitro metabolism of AOD9604. Drug Test Anal. 2015;7(1):31-8. PubMed 25208511 · DOI
- Wilding J. AOD-9604 Metabolic. Curr Opin Investig Drugs. 2004;5(4):436-40. PubMed 15134286
Laboratory note: solubility depends on salt form and solvent. This guide does not state a single solubility figure. Handling of lyophilized material is described in the peptide storage guide.
Research Use Only Notice
This guide is provided for educational and laboratory reference purposes. It summarizes published, primarily in-vitro and structural research literature and does not describe, recommend or imply any use in humans or animals. Products sold by Cleared Peptides are for laboratory research use only; they are not drugs, foods, cosmetics or dietary supplements, are not FDA-approved, and are not intended to diagnose, treat, cure, mitigate or prevent any disease. No dosing, administration or therapeutic information is provided.
