Last reviewed: October 2026 · Cleared Peptides research team
ACE-031 (ramatercept) is a recombinant fusion protein combining the extracellular ligand-binding domain of activin receptor type IIB (ActRIIB) with the Fc region of human IgG1. It acts as a soluble ligand trap for TGF-β superfamily members such as myostatin and activins.
ACE-031 Structure and Identifiers
| Name | ACE-031 |
|---|---|
| Synonyms | ActRIIB-Fc; ramatercept |
| CAS number | Not available. A single small-molecule CAS number is not assigned because this material is a recombinant protein preparation. |
| Structure | ActRIIB extracellular domain fused to IgG1 Fc |
| Form | Lyophilized powder |
Ligand Traps
Rather than blocking a receptor, a ligand trap binds circulating ligands so they cannot reach cell-surface receptors. Fc fusion dimerizes the construct and increases its stability.
Published In-Vitro Research Areas
- Ligand-binding and SMAD2/3 reporter assays
- Comparison with follistatin
This summary describes laboratory research only and makes no claim about effects in humans or animals.
Purity Testing and Storage
Every lot of ACE-031 supplied by Cleared Peptides is tested by an independent laboratory for identity and purity (or composition, for multi-component preparations), and the lot Certificate of Analysis is published on our COA page. Store lyophilized ACE-031 at −20 °C, sealed, dry and protected from light. Allow the vial to reach room temperature before opening and minimize freeze–thaw cycles. Handle according to your institution’s chemical-hygiene procedures.
Research materials referenced in this guide
Frequently Asked Questions
Is ACE-031 a peptide?
It is a recombinant fusion protein, much larger than a typical research peptide.
Is ACE-031 for human use?
No. Cleared Peptides supplies ACE-031 for laboratory research use only; it is not for human or veterinary use.
Selected References
Peer-reviewed literature on the compounds discussed in this guide, listed as scientific background for laboratory researchers. Citation does not imply endorsement by the authors or any use other than in-vitro research.
- George Carlson C, et al. Soluble activin receptor type IIB increases forward pulling tension in the mdx mouse. Muscle Nerve. 2011;43(5):694-9. PubMed 21462203 · DOI
Research Use Only Notice
This guide is provided for educational and laboratory reference purposes. It summarizes published, primarily in-vitro and structural research literature and does not describe, recommend or imply any use in humans or animals. Products sold by Cleared Peptides are for laboratory research use only; they are not drugs, foods, cosmetics or dietary supplements, are not FDA-approved, and are not intended to diagnose, treat, cure, mitigate or prevent any disease. No dosing, administration or therapeutic information is provided.
