Last reviewed: October 2026 · Cleared Peptides research team
PT-141 (bremelanotide) is a synthetic cyclic heptapeptide analog of α-melanocyte-stimulating hormone and a metabolite of melanotan II. It is characterized as an agonist at melanocortin receptors, principally MC3R and MC4R.
PT-141 Structure and Identifiers
| Name | PT-141 (bremelanotide) |
|---|---|
| CAS number | 189691-06-3 |
| PubChem CID | 9941379 |
| Molecular formula | C50H68N14O10 |
| Molecular weight | ≈1025.2 g/mol |
| Structure | Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH |
| Form | Lyophilized powder |
Structure
The lactam bridge between Asp and Lys cyclizes the core His-D-Phe-Arg-Trp melanocortin pharmacophore. The D-phenylalanine increases receptor potency and protease resistance relative to linear α-MSH.
Published In-Vitro Research Areas
- Melanocortin receptor (MC1R–MC5R) selectivity profiling
- cAMP signaling assays
Related: KPV, another α-MSH-derived peptide.
This summary describes laboratory research only and makes no claim about effects in humans or animals.
Purity Testing and Storage
Every lot of PT-141 supplied by Cleared Peptides is tested by an independent laboratory for identity and purity (or composition, for multi-component preparations), and the lot Certificate of Analysis is published on our COA page. Store lyophilized PT-141 at −20 °C, sealed, dry and protected from light. Allow the vial to reach room temperature before opening and minimize freeze–thaw cycles. Handle according to your institution’s chemical-hygiene procedures.
Research materials referenced in this guide
Frequently Asked Questions
Is PT-141 the same as bremelanotide?
Yes. Bremelanotide is the nonproprietary name for PT-141.
Is PT-141 for human use?
No. Cleared Peptides supplies PT-141 for laboratory research use only; it is not for human or veterinary use.
Selected References
Peer-reviewed literature on the compounds discussed in this guide, listed as scientific background for laboratory researchers. Citation does not imply endorsement by the authors or any use other than in-vitro research.
- Yuan XC, et al. Ligands for Melanocortin Receptors: Beyond Melanocyte-Stimulating Hormones and Adrenocorticotropin. Biomolecules. 2022;12(10). PubMed 36291616 · DOI
Laboratory note: solubility depends on salt form and solvent. This guide does not state a single solubility figure. Handling of lyophilized material is described in the peptide storage guide.
Research Use Only Notice
This guide is provided for educational and laboratory reference purposes. It summarizes published, primarily in-vitro and structural research literature and does not describe, recommend or imply any use in humans or animals. Products sold by Cleared Peptides are for laboratory research use only; they are not drugs, foods, cosmetics or dietary supplements, are not FDA-approved, and are not intended to diagnose, treat, cure, mitigate or prevent any disease. No dosing, administration or therapeutic information is provided.
