Last reviewed: October 2026 · Cleared Peptides research team
FOXO4-DRI is a 46-residue peptide built from D-amino acids in reversed order (a D-retro-inverso design) to mimic a region of the transcription factor FOXO4. It was described by Baar and colleagues in 2017 as a tool to interfere with the FOXO4–p53 interaction in senescent cells.
FOXO4-DRI Structure and Identifiers
| Name | FOXO4-DRI |
|---|---|
| Synonyms | FOXO4 D-retro-inverso peptide |
| CAS number | 2460055-10-9 |
| PubChem CID | 167312269 |
| Molecular formula | C228H388N86O64 |
| Molecular weight | ≈5358.1 g/mol |
| Structure | All-D retro-inverso 46-mer |
| Form | Lyophilized powder |
D-Retro-Inverso Design
Reversing the sequence and using D-amino acids preserves the side-chain topology of the parent L-peptide while making the backbone resistant to proteases — a common strategy for stabilizing research peptides.
Published In-Vitro Research Areas
- Senescent-cell viability assays in culture
- FOXO4–p53 interaction and localization studies
This summary describes laboratory research only and makes no claim about effects in humans or animals.
Purity Testing and Storage
Every lot of FOXO4-DRI supplied by Cleared Peptides is tested by an independent laboratory for identity and purity (or composition, for multi-component preparations), and the lot Certificate of Analysis is published on our COA page. Store lyophilized FOXO4-DRI at −20 °C, sealed, dry and protected from light. Allow the vial to reach room temperature before opening and minimize freeze–thaw cycles. Handle according to your institution’s chemical-hygiene procedures.
Research materials referenced in this guide
Frequently Asked Questions
What does DRI stand for?
D-retro-inverso: the peptide uses D-amino acids in reverse sequence order.
Is FOXO4-DRI for human use?
No. Cleared Peptides supplies FOXO4-DRI for laboratory research use only; it is not for human or veterinary use.
Selected References
Baar MP, et al. Targeted apoptosis of senescent cells restores tissue homeostasis in response to chemotoxicity and aging. Cell. 2017;169(1):132-147.e16. PubMed 28340339. Cited as the laboratory report of a D-retro-inverso peptide directed at a FOXO4–p53 interaction in cell experiments. Outcome wording in the paper title is not repeated as a claim on this site.
Laboratory note: solubility depends on salt form and solvent. This guide does not state a single solubility figure. Handling of lyophilized material is described in the peptide storage guide.
Research Use Only Notice
This guide is provided for educational and laboratory reference purposes. It summarizes published, primarily in-vitro and structural research literature and does not describe, recommend or imply any use in humans or animals. Products sold by Cleared Peptides are for laboratory research use only; they are not drugs, foods, cosmetics or dietary supplements, are not FDA-approved, and are not intended to diagnose, treat, cure, mitigate or prevent any disease. No dosing, administration or therapeutic information is provided.
