Last reviewed: October 2026 · Cleared Peptides research team
Snap-8 (acetyl octapeptide-3, also listed as acetyl glutamyl heptapeptide-3) is an eight-residue peptide modelled on the N-terminal end of the SNAP-25 protein. It is an elongated analog of the hexapeptide argireline and is studied in SNARE-complex research.
Snap-8 Structure and Identifiers
| Name | Snap-8 |
|---|---|
| Synonyms | Acetyl octapeptide-3; acetyl glutamyl heptapeptide-3 |
| CAS number | 868844-74-0 |
| PubChem CID | 76283482 |
| Molecular formula | C41H70N16O16S |
| Molecular weight | ≈1075.2 g/mol |
| Sequence | Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2 |
| Form | Powder |
Design Rationale
SNAP-25 is one of three proteins that form the SNARE complex required for vesicle fusion. Peptides mimicking its N-terminus are studied as competitive inhibitors of SNARE assembly in biochemical assays.
Published In-Vitro Research Areas
- SNARE-complex assembly assays
- Cosmetic-science formulation research
This summary describes laboratory research only and makes no claim about effects in humans or animals.
Purity Testing and Storage
Every lot of Snap-8 supplied by Cleared Peptides is tested by an independent laboratory for identity and purity (or composition, for multi-component preparations), and the lot Certificate of Analysis is published on our COA page. Store lyophilized Snap-8 at −20 °C, sealed, dry and protected from light. Allow the vial to reach room temperature before opening and minimize freeze–thaw cycles. Handle according to your institution’s chemical-hygiene procedures.
Frequently Asked Questions
How does Snap-8 differ from argireline?
Snap-8 is two residues longer than the argireline hexapeptide, extending the SNAP-25-derived sequence.
Is Snap-8 for human use?
No. Cleared Peptides supplies Snap-8 for laboratory research use only; it is not for human or veterinary use.
Selected References
Peer-reviewed literature on the compounds discussed in this guide, listed as scientific background for laboratory researchers. Citation does not imply endorsement by the authors or any use other than in-vitro research.
- Ferrer-Montiel AV, et al. The 26-mer peptide released from SNAP-25 cleavage by botulinum neurotoxin E inhibits vesicle docking. FEBS Lett. 1998;435(1):84-8. PubMed 9755864 · DOI
- Gutierrez LM, et al. A peptide that mimics the C-terminal sequence of SNAP-25 inhibits secretory vesicle docking in chromaffin cells. J Biol Chem. 1997;272(5):2634-9. PubMed 9006897 · DOI
Laboratory note: solubility depends on salt form and solvent. This guide does not state a single solubility figure. Handling of lyophilized material is described in the peptide storage guide.
Research Use Only Notice
This guide is provided for educational and laboratory reference purposes. It summarizes published, primarily in-vitro and structural research literature and does not describe, recommend or imply any use in humans or animals. Products sold by Cleared Peptides are for laboratory research use only; they are not drugs, foods, cosmetics or dietary supplements, are not FDA-approved, and are not intended to diagnose, treat, cure, mitigate or prevent any disease. No dosing, administration or therapeutic information is provided.
