Last reviewed: October 2026 · Cleared Peptides research team
KPV is the tripeptide Lys-Pro-Val, corresponding to residues 11–13 at the C-terminus of α-melanocyte-stimulating hormone (α-MSH). It is one of the smallest bioactive fragments studied from the melanocortin family and a convenient tool compound for peptide-transport and inflammatory-signaling research.
KPV Structure and Identifiers
| Name | KPV |
|---|---|
| Synonyms | Lys-Pro-Val; α-MSH (11–13) |
| CAS number | 67727-97-3 |
| PubChem CID | 125672 |
| Molecular formula | C16H30N4O4 |
| Molecular weight | ≈342.4 g/mol |
| Sequence | Lys-Pro-Val |
| Form | Lyophilized powder |
Origin in the Melanocortin System
α-MSH is a 13-residue peptide derived from pro-opiomelanocortin (POMC). Its C-terminal tripeptide KPV was identified as a fragment that retains activity in several anti-inflammatory assay systems while lacking the full melanocortin-receptor pharmacophore (His-Phe-Arg-Trp), which makes it useful for separating receptor-dependent and receptor-independent effects.
Published In-Vitro Research Areas
- NF-κB and MAPK signaling in epithelial and immune-cell models
- Uptake through the di/tripeptide transporter PepT1 in intestinal epithelial cells
- Cytokine-expression assays
- Nanoparticle and delivery-formulation studies
This summary describes laboratory research only and makes no claim about effects in humans or animals.
Purity Testing and Storage
Every lot of KPV supplied by Cleared Peptides is tested by an independent laboratory for identity and purity (or composition, for multi-component preparations), and the lot Certificate of Analysis is published on our COA page. Store lyophilized KPV at −20 °C, sealed, dry and protected from light. Allow the vial to reach room temperature before opening and minimize freeze–thaw cycles. Handle according to your institution’s chemical-hygiene procedures.
Research materials referenced in this guide
Frequently Asked Questions
What is KPV derived from?
KPV is the C-terminal tripeptide (residues 11–13) of α-MSH.
What is the CAS number of KPV?
67727-97-3; molecular formula C16H30N4O4.
Is KPV for human use?
No. Cleared Peptides supplies KPV for laboratory research use only; it is not for human or veterinary use.
Selected References
Peer-reviewed literature on the compounds discussed in this guide, listed as scientific background for laboratory researchers. Citation does not imply endorsement by the authors or any use other than in-vitro research.
- Catania A, et al. The neuropeptide alpha-MSH in host defense. Ann N Y Acad Sci. 2000;917:227-31. PubMed 11268348 · DOI
- Ichiyama T, et al. The neuroimmunomodulatory peptide alpha-MSH. Ann N Y Acad Sci. 2000;917:221-6. PubMed 11268347 · DOI
Laboratory note: solubility depends on salt form and solvent. This guide does not state a single solubility figure. Handling of lyophilized material is described in the peptide storage guide.
Research Use Only Notice
This guide is provided for educational and laboratory reference purposes. It summarizes published, primarily in-vitro and structural research literature and does not describe, recommend or imply any use in humans or animals. Products sold by Cleared Peptides are for laboratory research use only; they are not drugs, foods, cosmetics or dietary supplements, are not FDA-approved, and are not intended to diagnose, treat, cure, mitigate or prevent any disease. No dosing, administration or therapeutic information is provided.
