Last reviewed: October 2026 · Cleared Peptides research team
Cagrilintide and semaglutide are two acylated peptides that act on different receptor systems — amylin/calcitonin receptors and the GLP-1 receptor respectively. Their combination is referred to in the literature as “CagriSema”. This guide explains each component and why the pairing is studied.
In this guide:
What Is Cagrilintide?
Cagrilintide (AM833, CAS 1415456-99-3) is a long-acting analog of amylin, a 37-residue peptide hormone co-secreted with insulin. Native human amylin aggregates readily; cagrilintide’s sequence modifications improve solubility and stability, and a C20 fatty diacid side chain provides albumin binding. In vitro it is characterized as a non-selective agonist at amylin receptors (AMY1–3, calcitonin receptor + RAMP complexes) and at the calcitonin receptor.
What Is Semaglutide?
Semaglutide (CAS 910463-68-2) is an acylated GLP-1(7–37) analog and selective GLP-1 receptor agonist. Read the full semaglutide research guide.
Why Are Cagrilintide and Semaglutide Studied Together?
Amylin receptors and the GLP-1 receptor are distinct GPCR systems that are both expressed in tissues of interest to metabolic-signaling research. Pairing an amylin analog with a GLP-1 analog lets researchers examine co-activation of two independent receptor pathways — a different strategy from single-molecule multi-agonists such as tirzepatide or retatrutide.
Specifications
| Cagrilintide | Semaglutide | |
|---|---|---|
| CAS | 1415456-99-3 | 910463-68-2 |
| Formula | C194H312N54O59S2 | C187H291N45O59 |
| MW | ≈4409.0 g/mol | ≈4113.6 g/mol |
| Receptors | Amylin (AMY1–3), calcitonin | GLP-1R |
| Lipid chain | C20 diacid | C18 diacid |
Cleared Peptides offers both cagrilintide (CP-Cag) and a pre-combined cagrilintide + semaglutide research blend (CP-Cagri-S), each with an independent lot COA on our COA page.
Research materials referenced in this guide
Frequently Asked Questions
What is CagriSema?
CagriSema is the name used in the literature for the combination of cagrilintide (an amylin analog) and semaglutide (a GLP-1 analog).
What is the CAS number of cagrilintide?
1415456-99-3; molecular formula C194H312N54O59S2.
Is CP-Cagri-S a pharmaceutical product?
No. It is a research-grade vial containing both peptides, for laboratory research use only.
Selected References
Peer-reviewed literature on the compounds discussed in this guide, listed as scientific background for laboratory researchers. Citation does not imply endorsement by the authors or any use other than in-vitro research.
- Kruse T, et al. Development of Cagrilintide, a Long-Acting Amylin Analogue. J Med Chem. 2021;64(15):11183-11194. PubMed 34288673 · DOI
- Cao J, et al. Structural and dynamic features of cagrilintide binding to calcitonin and amylin receptors. Nat Commun. 2025;16(1):3389. PubMed 40204768 · DOI
- Lau J, et al. Discovery of the Once-Weekly Glucagon-Like Peptide-1 (GLP-1) Analogue Semaglutide. J Med Chem. 2015;58(18):7370-80. PubMed 26308095 · DOI
- Knudsen LB, et al. The Discovery and Development of Liraglutide and Semaglutide. Front Endocrinol (Lausanne). 2019;10:155. PubMed 31031702 · DOI
Research Use Only Notice
This guide is provided for educational and laboratory reference purposes. It summarizes published, primarily in-vitro and structural research literature and does not describe, recommend or imply any use in humans or animals. Products sold by Cleared Peptides are for laboratory research use only; they are not drugs, foods, cosmetics or dietary supplements, are not FDA-approved, and are not intended to diagnose, treat, cure, mitigate or prevent any disease. No dosing, administration or therapeutic information is provided.
